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Dry Twist is a Mid-World disease that affects the joints, similar to arthritis. It is quick spreading and will eventually lead to death.
Roland Deschain believed himself to be afflicted with the disease in Wolves of the Calla. He had Rosalita Munoz treat it with her special remedy. His joint pain went away after the death of Jake Chambers; he had been experiencing the pain that the car accident would cause Stephen King.